Researchers in the US treated healthy mice with a form of gene therapy that refreshed older cells, making the animals more youthful according to biological markers that are used to measure the effects of aging.
美國研究人員對健康老鼠實施了一種更新老化細胞的基因療法并獲得成功,通過生物標記法他們測出這些老鼠變年輕了。
The findings will fuel interest in radical new therapies that aim to slow or reverse the aging process as a means of tackling age-related diseases such as cancer, brittle bones and Alzheimer’s.
這一發(fā)現(xiàn)會點燃人們對以延緩或逆轉衰老為目標的激進新療法的興趣,這種療法可以用來治療癌癥、骨質疏松和老年癡呆癥等老年常見疾病。
The scientists drew on previous work by the Japanese Nobel laureate Prof Shinya Yamanaka, who showed that a mixture of four molecules – known as Yamanaka factors – can rewind adult cells into youthful stem cells that are capable of forming almost any tissue in the body.
美國科學家的這一療法借鑒了日本諾貝爾獎得主山中伸彌教授先前的研究成果。山中伸彌向世人展示,被稱為“山中因子”的四種分子組合在一起可以讓成人細胞逆生長為年輕的干細胞,而干細胞可以分化成人體的任何組織。
The US team found that mice who received Yamanaka factors for several months resembled younger animals in many ways, with their skin and kidneys in particular showing signs of rejuvenation.
美國團隊發(fā)現(xiàn),連續(xù)數(shù)月注射山中因子的老鼠在很多方面都變得像年輕老鼠,皮膚和腎臟的回春跡象尤為明顯。